Molecular Optimization of Calcineurin Inhibitors for Prion Disease by Saumya Patel
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Author: Saumya Patel
Page Count: 80 pages
Published Date: 16 Jun 2012
Publisher: LAP Lambert Academic Publishing
Publication Country: Saarbrucken, Germany
Language: English
Type: eBook
ISBN: 9783659158957
File size: 21 Mb
File Name: Molecular.Optimization.of.Calcineurin.Inhibitors.for.Prion.Disease.pdf
Download Link: Molecular Optimization of Calcineurin Inhibitors for Prion Disease
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This study mainly emphasizes on pharmacophore features available in the immunosuppressant drugs, especially Calcineurin inhibitors for human prion diseases. The structural and functional properties of FK506/Tacrolimus - a drug used for treatment of human prion diseases were enhanced through pharmacophore-assisted molecular optimization approach. Important pharmacophore features responsible for interaction with active site and intramolecular structural stability were elucidated.
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